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KMID : 0379120060340010015
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Korean Journal of Mycology
2006 Volume.34 No. 1 p.15 ~ p.21
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Articles : Screening of Bioactive Compounds from Mushroom Pholiota sp.
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You Hyung-Eeun
Lee Jong-Soo
Seo Geon-Sik
Jo Soo-Mook
Lee Byoung-Seok
Lee Dae-Hyoung
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Abstract
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Extracts from 63 kinds of Pholiota sp. fruiting bodies were prepared using water and methanol, and then their physiological functionalities were investigated. The methanol extracts from Pholiota adiposa PAD030 showed high fibrinolytic activity and those of P. adiposa ASI PAD-022 showed potential inhibitory activity of 76.8% against ${\beta}-hydroxy-{\beta}-methylglutaryl(HMG)-CoA$ reductase. The highest antioxidant and tyrosinase inhibitory activities were found in the water extracts of Pholiota sp. PSP-015 (72.7%) and methanol extracts of P. nameko PNA-024 (69.5%), respectively. However, superoxide dismutase(SOD)-like activity and elastase inhibitory activity were low in almost of the extracts. The HMG-CoA reductase inhibitor from the fruiting body of P. adiposa PAD-022 which showed the highest functionality was extracted maximally when powder of the fruiting body was shaked at $30^{\circ}C$ for 12 h by methanol and its HMG-CoA reductase inhibitory activity was 80.2%.
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KEYWORD
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Bioactive compound, HMG-CoA reductase inhibitor, Pholiota sp.
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